Endocrine Abstracts

The binding characteristics of maternal serum human chorionic gonadotrophin (hCG) to immobilised lectins, specifically Concanavalin A (Con A), Lens culinaris agglutinin (LCA) and Wheat germ agglutinin (WGA), have been shown be compatible with the proposed glycosyl structures of hCG as inferred from other analytical methods. We have shown that serum hCG from groups of pregnant women with or without type 1 diabetes show identical affinity for Con A and LCA, but serum hCG from th...

Annexin I (ANXA1), a Ca2+- and phospholipid-binding protein is an important mediator of glucocorticoid (GC) action in the host defence and neuroendocrine systems. In the anterior pituitary ANXA1 is highly expressed by the folliculo-stellate (FS) cells (1). We have shown that GCs cause the externalization of annexin I in a FS cell line (murine TtT/GF) despite the fact that ANXA1 lacks a signal sequence and is not packaged in secretory granules. In bacteria and yeast ...